Of course, air-conditioning will give better control of the indoor temperature and then improve comfort and productivity. But there also exist many examples of discomfort in air-conditioned buildings due to draught, noise and sick building syndrome. By air-conditioning, heating, cooling and ventilation are achieved alone by air, where the cooling and heating requirements determine the amount of required air circulation. Alternatively, the heating and sensible component of cooling may be done by hydronic radiant heating and cooling systems, where pipes are embedded in concrete slabs between each storey. The system may be combined with a ventilationz system, where the amount of outside air is based on the requirements for acceptable are quality. This paper discusses the possibilities and limitations of such heating and cooling systems, and examples of buildings having this type of systems are presented.